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AMG 208
Synonyms:
CAS NO: 1002304-34-8
Molecular Formula: C22H17N5O2
Molecular Weight: 383.40
Purity: 98% min
Solubility: In DMSO
Storage: -20°C
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Remarks: AMG 208 is a selective small-molecule inhibitor of the proto-oncogene c-Met with potential antineoplastic activity. c-Met inhibitor AMG 208 inhibits the ligand-dependent and ligand-independent activation of c-Met, inhibiting its tyrosine kinase activity, which may result in cell growth inhibition in tumors that overexpress c-Met. C-Met encodes the hepatocyte growth factor receptor tyrosine kinase, plays an important role in epithelial cell proliferation and has been shown to be overexpressed in a variety of cancers.

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